"The proper management of pain remains, after all, the most important obligation, the main objective, and the crowning achievement of every physician."

John Bonica

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Ronald Melzack

“Pain is not simply the end product of a linear sensory transmission system; it is a dynamic process that involves continuous interactions among complex ascending and descending systems. The neuromatrix theory guides us away from the Cartesian concept of pain as a sensation produced by injury, inflammation, or other tissue pathology and toward the concept of pain as a multidimensional experience produced by multiple influences.”